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Hironobu Sasano Selected Research

Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)

1/2022Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
10/2019The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant "neoplastic" steroidogenesis in adrenals.
11/2017Evaluation of Cortisol Production in Aldosterone-Producing Adenoma.
1/2017Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3.
2/2016Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17.
1/2016Expression of steroidogenic enzymes and their transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and quantitative real-time polymerase chain reaction studies.
7/2014Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.

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Hironobu Sasano Research Topics

Disease

279Neoplasms (Cancer)
08/2022 - 01/2000
182Breast Neoplasms (Breast Cancer)
06/2022 - 01/2002
96Carcinoma (Carcinomatosis)
06/2022 - 01/2000
78Adenoma (Adenomas)
02/2022 - 03/2002
62Hyperaldosteronism (Conn Syndrome)
03/2022 - 03/2002
33Neoplasm Metastasis (Metastasis)
06/2022 - 01/2000
32Cushing Syndrome
07/2021 - 07/2002
30Hyperplasia
09/2021 - 03/2002
25Hypertension (High Blood Pressure)
01/2022 - 07/2002
24Adrenocortical Adenoma (Disease, Conn's)
07/2021 - 08/2003
23Adrenocortical Carcinoma
01/2022 - 04/2006
20Ductal Carcinoma
06/2022 - 02/2004
17Noninfiltrating Intraductal Carcinoma (DCIS)
09/2018 - 03/2006
16Endometrial Neoplasms (Endometrial Cancer)
03/2022 - 06/2002
16Neuroendocrine Tumors (Neuroendocrine Tumor)
02/2022 - 07/2007
16Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 07/2005
14Lymphatic Metastasis
01/2022 - 02/2004
14Pheochromocytoma
10/2021 - 01/2000
13Lung Neoplasms (Lung Cancer)
02/2022 - 07/2011
13Adenocarcinoma
06/2020 - 06/2002
12Adenocarcinoma of Lung
01/2022 - 08/2010
12Hypokalemia
09/2020 - 03/2002
11Esophageal Squamous Cell Carcinoma
06/2022 - 02/2010
11Triple Negative Breast Neoplasms
03/2020 - 05/2013
11Prostatic Neoplasms (Prostate Cancer)
01/2019 - 07/2004
9Ovarian Neoplasms (Ovarian Cancer)
02/2019 - 07/2002
9Ovarian Epithelial Carcinoma
05/2010 - 07/2002
8Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2022 - 09/2003
8Hepatocellular Carcinoma (Hepatoma)
10/2021 - 08/2002
8Carcinogenesis
07/2021 - 01/2000
8Disease Progression
01/2021 - 01/2005
7Acth-Independent Macronodular Adrenal Hyperplasia
09/2017 - 04/2002
6Obesity
01/2022 - 01/2013
6Inflammation (Inflammations)
06/2020 - 02/2002
6Fibrosis (Cirrhosis)
12/2019 - 01/2003

Drug/Important Bio-Agent (IBA)

118Estrogens (Estrogen)FDA Link
03/2022 - 01/2002
92AldosteroneIBA
03/2022 - 03/2002
88EnzymesIBA
01/2022 - 01/2002
79Estrogen ReceptorsIBA
06/2022 - 02/2004
67Messenger RNA (mRNA)IBA
01/2022 - 03/2002
66Biological ProductsIBA
01/2022 - 01/2002
66SteroidsIBA
01/2022 - 01/2002
63Hydrocortisone (Cortisol)FDA LinkGeneric
02/2022 - 04/2002
63Aromatase (CYP19)IBA
04/2021 - 01/2002
62Proteins (Proteins, Gene)FDA Link
08/2022 - 02/2002
57AndrogensIBA
03/2022 - 06/2002
57Hormones (Hormone)IBA
08/2021 - 01/2003
41Aromatase InhibitorsIBA
08/2021 - 09/2003
36Progesterone Receptors (Progesterone Receptor)IBA
01/2022 - 07/2002
32Biomarkers (Surrogate Marker)IBA
06/2022 - 09/2005
31Adrenocorticotropic Hormone (ACTH)FDA Link
10/2021 - 03/2002
26Cytochrome P-450 CYP11B2 (CYP11B2)IBA
03/2022 - 08/2004
26Androgen Receptors (Androgen Receptor)IBA
01/2021 - 06/2002
25Oxidoreductases (Dehydrogenase)IBA
10/2021 - 04/2005
20Estradiol (Delestrogen)FDA LinkGeneric
03/2021 - 05/2003
20Steryl-Sulfatase (Steroid Sulfatase)IBA
01/2021 - 01/2002
15ErbB Receptors (EGF Receptor)IBA
08/2022 - 12/2008
153 (or 17)-beta-hydroxysteroid dehydrogenaseIBA
06/2010 - 01/2002
14ReninIBA
01/2022 - 03/2002
14Estrogen Receptor alphaIBA
01/2017 - 05/2003
13GlucocorticoidsIBA
06/2020 - 01/2003
13Estrogen Receptor betaIBA
01/2017 - 03/2004
12ProgesteroneFDA LinkGeneric
11/2018 - 07/2002
11TamoxifenFDA LinkGeneric
06/2022 - 07/2004
11LigandsIBA
01/2022 - 07/2006
11Protein Isoforms (Isoforms)IBA
07/2021 - 05/2002
11estrone sulfotransferaseIBA
01/2021 - 01/2002
11Dehydroepiandrosterone (DHEA)IBA
11/2020 - 09/2003
10Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
02/2022 - 07/2007
10Phenobarbital (Luminal)FDA Link
12/2021 - 03/2006
10Transcription Factors (Transcription Factor)IBA
07/2021 - 09/2003
10LipidsIBA
01/2021 - 05/2009
9Formaldehyde (Formol)FDA Link
12/2021 - 09/2005
9ParaffinIBA
12/2021 - 01/2004
9Tyrosine Kinase InhibitorsIBA
08/2021 - 10/2014
9MicroRNAs (MicroRNA)IBA
01/2021 - 01/2010
9exemestane (Aromasin)FDA Link
09/2019 - 06/2010
9Steroid Receptors (Steroid Receptor)IBA
01/2019 - 05/2003
9Testosterone (Sustanon)FDA Link
01/2017 - 06/2002
8Monoclonal AntibodiesIBA
08/2022 - 05/2005
8CytokinesIBA
01/2021 - 01/2008
8EstroneFDA Link
05/2011 - 05/2003
7DNA (Deoxyribonucleic Acid)IBA
06/2022 - 10/2007
7Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA
01/2022 - 07/2014
7human ERBB2 proteinIBA
12/2021 - 03/2012
7CatecholaminesIBA
10/2021 - 01/2016
711-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)IBA
01/2008 - 11/2002
6Hydroxysteroid DehydrogenasesIBA
06/2022 - 04/2005
6Trastuzumab (Herceptin)FDA Link
12/2021 - 10/2007
6VimentinIBA
11/2020 - 11/2006
6Glucose (Dextrose)FDA LinkGeneric
01/2020 - 07/2006
6PotassiumIBA
09/2017 - 07/2002
6Small Interfering RNA (siRNA)IBA
04/2017 - 02/2009
6Pharmaceutical PreparationsIBA
03/2017 - 01/2008
6RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2012 - 06/2002

Therapy/Procedure

106Therapeutics
06/2022 - 06/2003
33Adrenalectomy
01/2022 - 03/2002
20Drug Therapy (Chemotherapy)
12/2021 - 01/2009
15Neoadjuvant Therapy
06/2022 - 10/2005
14Lasers (Laser)
01/2022 - 06/2003